[Cisplatin cochlear toxicity in an experimental model].

Cisplatin is a chemotherapeutical agent that is highly effective in the treatment of solid organ tumours, such as ovarian, testicular, bladder, non-small cell pulmonary, and head and neck tumours. The main side effects associated with the use of cisplatin are gastrointestinal toxicity, nephrotoxicity, myelotoxicity, peripheral neurotoxicity and ototoxicity. Ototoxic lesions cause bilateral neurosensory hearing loss, which is irreversible, cumulative and dosage-dependent from